Winners for the 15th Hypertension Research Awards and outstanding papers in Hypertension Research

At the general meeting of the conference held on October 13th, the Japanese Society of Hypertension (JSH) 15th Hypertension Research Awards were announced. These awards were established in 2010 and are presented to papers that have made significant contributions to the advancement of hypertension research over the past year. From among numerous original articles published in Hypertension Research, from the April issue 2023 to the March issue 2024, the editorial committee members of the Hypertension Research journal have selected three award-winning papers this year. We extend our heartfelt congratulations to the recipients. Along with a recent photo of the awardees, we would like to introduce the key findings of the award-winning papers.

Hypertension Research Excellence Award

The 2024 recipient of this award was Dr. Satoyuki Ogino and colleagues from the Department of Anatomy, Kyorin University School of Medicine, Mitaka, Japan, for the paper entitled “Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy,” [1] is a basic research that examined the expression of Piezo1 and its signaling cascade in a glomerular effect model. This research utilized hypertensive nephropathy mice and cultured podocytes to investigate Piezo1, a mechanosensor that was a candidate for the 2021 Nobel Prize in Physiology or Medicine. The research demonstrated an increase in Piezo1 expression, activation of Rac1, and the induction of expression for podocyte injury-related genes such as Pai1, Sgk1, and Mcp1. These gene inductions were found to improve with the normalization of blood pressure through the administration of mineralocorticoid receptor antagonists. This interesting research provides insight into how the stretch load caused by hypertension is directly involved in the mechanisms of renal injury, thereby explaining part of the reversible renal protective effects achieved through blood pressure reduction.

Dr. Satoyuki Ogino

Hypertension Research Award

This award was given to Dr. Ren Mizoguchi and colleagues from the School of Biological Science and Technology, College of Science and Engineering, Kanazawa University, Kanazawa, Japan, for their paper entitled “Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results,” [2] is an epidemiological study that examined the relationship between gut microbiota and the renin-angiotensin-aldosterone system (RAAS). By using machine learning techniques for analysis, the study evaluated 16SrRNA sequencing of gut microbiota in conjunction with clinical data related to RAAS, revealing that gut bacterial genera such as Blautia, Bacteroides, Akkermansia, and Bifidobacterium are associated with RAAS. Further research is anticipated to explore how gut microbiota may influence racial and regional variations in salt sensitivity and whether it could serve as a target for antihypertensive therapies.

Dr. Ren Mizoguchi

Hypertension Research Award

This award was given to Dr. Kosuke Tanaka and colleagues, from the Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, for the paper entitled “Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children’s Study,” [3] which is an epidemiological study based on data from the large-scale prospective cohort study known as the Japan Environment and Children’s Study (JECS), which focused on pregnant women throughout Japan. The research found that exposure to secondhand smoke for four days or more a week was associated with an over 18% increased risk of pregnancy-induced hypertension, while exposure for more than two hours a day was linked to a 27% increase in risk. This study carries significant social implications.

Dr. Kosuke Tanaka

Website: International Research Awards

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