How Multi-Organ Cancer Genes Shape Gastric Cancer Risk

 

International Research Awards

How Multi-Organ Cancer Genes Shape Gastric Cancer Risk

Understanding how multi-organ cancer genes influence the development of gastric cancer is critical in unraveling its genetic complexity and improving early detection. These genes, often implicated in multiple cancer types (such as breast, colorectal, and ovarian), may carry mutations or alterations that significantly increase susceptibility to gastric malignancies. Recent genomic research reveals that variants in tumor suppressors like TP53, BRCA1/2, and CDH1—originally linked to other cancers—also play pivotal roles in gastric cancer pathways. By mapping these shared genetic pathways, scientists can better predict individual risk, tailor precision oncology, and uncover potential therapeutic targets across cancer types. This cross-cancer genetic insight is vital for early intervention and personalized medicine in gastric cancer.

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