New drug target discovered for devastating “brain on fire” disease
- Scientists have zeroed in on a critical weak spot behind a rare but devastating brain autoimmune disorder often known as “Brain on Fire.” The disease strikes when the immune system attacks NMDA receptors—key molecules involved in memory and thinking—leading to psychiatric symptoms, seizures, and even death. Researchers have identified a precise “hot spot” on a key brain receptor that’s attacked in a rare and dangerous autoimmune disease. Targeting this site could lead to smarter treatments—and possibly earlier diagnosis. Credit: AI/ScienceDaily.com
Researchers have uncovered a promising new treatment target for a severe autoimmune brain disorder. The finding could help drive the development of more precise therapies for a condition caused by the immune system attacking a critical brain receptor known as the NMDA receptor. It may also open the door to a future blood test that could detect signs of the disease earlier and allow patients to begin treatment sooner.
The research was conducted at Oregon Health & Science University and published in the journal Science Advances.
The Disease Behind "Brain on Fire"
Many people recognize this disorder from the bestselling memoir and the 2016 film "Brain on Fire." Although widely publicized, the condition is rare, affecting roughly 1 in 1 million people each year, most often adults in their 20s and 30s.
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